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What Are CO2 Cannabis Extracts and How Are They Made?

Dr. Saira Zulfiqar, PharmD

Written by: Dr. Saira Zulfiqar

Updated on March 10, 2025

Cannabis-Oil-from-Extraction

Whether you enjoy using vaporizer pens, topical salves, infused edibles, or specialized elixirs, you’ve likely encountered products made with carbon dioxide (CO2) supercritical fluid extraction. Although CO2 extraction is a relatively recent trend in cannabis concentrate processing, the technology has long been established in botanical extractions. Today, its application in cannabis is rapidly positioning it as a leading method for industrial hash oil production. This shift is driven by the process’s versatility, sustainability, and enhanced safety features.

In the consumer market, you’ll notice that more and more brands are clearly labeling their concentrates by the extraction method used, distinguishing between those that utilize petroleum-based solvents (like butane or propane) and those that use a more natural approach with CO2. But what exactly is a CO2 extract, and how is it produced?

What Is Supercritical CO2 Extraction?

Supercritical fluid extraction (SFE) is a technique that separates components from a mixture by using a solvent under conditions of extreme temperature and pressure. In these conditions, the solvent enters a supercritical state, where it exhibits properties of both a liquid and a gas. This unique state allows the solvent to efficiently penetrate the material and break down cellular structures to release active compounds.

Among various supercritical solvents, CO2 is the most commonly used due to its low toxicity and environmental friendliness. Having been employed since the 1980s and 90s for processes such as decaffeinating coffee and extracting essential oils, supercritical CO2 extraction has become a trusted, clean, and efficient method across multiple industries, including the rapidly evolving cannabis market.

Benefits of Using CO2 Extraction

At standard temperature and pressure, CO2 exists as a gas. However, by cooling it to extremely low temperatures and applying pressure, CO2 transitions into a liquid and then into a supercritical state. Under controlled conditions, this supercritical CO2 acts as a highly effective solvent, capable of dissolving and fractionating active compounds from cannabis. Here are several key advantages:

  • Natural and Safe: CO2 is a naturally occurring compound that our bodies produce. It is far safer than petroleum-based solvents, which are often associated with environmental and health concerns. In fact, the FDA has recognized CO2 as safe for industrial extractions.
  • Mild Extraction Conditions: The transformation to a supercritical state can occur at temperatures below 90°F, ensuring that the delicate volatile compounds and terpenes in cannabis are preserved without degradation.
  • High Customizability: The solubility of CO2 changes with pressure, allowing precise fractionation of the diverse range of cannabinoids and terpenes found in cannabis. This means compounds such as THCA, CBD, CBG, THCV, and various aromatic terpenes can be selectively extracted.

CO2 Extraction Equipment and Process

The equipment and methods used in supercritical CO2 extraction can vary greatly depending on production scale. Industrial systems designed for high-volume output can cost hundreds of thousands of dollars and require operation by highly trained professionals in a controlled lab environment.

The process typically follows these steps:

  1. CO2 Conditioning: Gaseous CO2 is first cooled to around -70°F and pressurized until it converts into a liquid. Further adjustments in temperature and pressure then bring it into a supercritical state, where it gains enhanced solvating properties.
  2. Material Extraction: The supercritical CO2 is introduced into a chamber containing raw cannabis material. Its unique properties allow it to penetrate the plant tissue efficiently, dissolving the trichome membranes to capture a wide range of active compounds.
  3. Separation and Fractionation: The compound-enriched CO2 then passes into a secondary pressurized vessel. Here, changes in pressure and temperature help to fractionate and separate cannabinoids and terpenes from the solvent.
  4. CO2 Recycling: Finally, the remaining CO2 is directed to a condenser where it reverts to its gaseous state. Many industrial systems operate on a closed-loop basis, recycling the CO2 to enhance cost efficiency and environmental sustainability.

Applications of CO2 Extracts in the Cannabis Industry

Once the compounds have been separated using supercritical CO2 extraction, further refining processes such as winterization and distillation are often applied to create a stable, market-ready product. Additional steps may include terpene reintegration, where the separated terpenes are blended back into a refined cannabinoid solution to provide a richer flavor profile for vaporizer products. Conversely, if the final product is intended for culinary use, this step might be skipped to maintain a neutral flavor.

The flexibility of CO2 extraction enables the production of a wide array of cannabis products, ranging from vaporizer oils to concentrates designed for dabbing (such as waxes, crumbles, shatters, and saps). Although the initial investment in CO2 extraction technology might be higher compared to other methods, its safety, environmental benefits, and customizability make it a highly attractive option for modern cannabis processing. As the technology continues to mature, its contribution to the cannabis industry is expected to grow, setting new benchmarks for quality and efficiency.

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Dr. Saira Zulfiqar, PharmD
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